Answer by asbjornenge for Node Webkit clear cache

The require cache is apparently only available on global.require.cache.

Clearing that cache manually made it work for me.

for(module in global.require.cache){    if(global.require.cache.hasOwnProperty(module)){        delete global.require.cache[module];    }}location.reload()

Neither the gui.APP.clearCache() nor the gui.Window.get().reloadIgnoringCache() had any effect for me.